| Title | [Preparation and characterization of artemether-iron sucrose lipid nanoparticles] | | Author(s) | Yan T, Zhang ZR, Liu J, Gong T | | Institution | Key Laboratory of Durg Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. | | Source | Sichuan Da Xue Xue Bao Yi Xue Ban 2009 Jul; 40(4):724-6, 740. | | Abstract | OBJECTIVE: To prepare Artemether-Iron Sucrose lipid nanoparticles and examine the characteristics of the nanoparticles.
METHODS: The Artemether-Iron Sucrose lipid nanoparticles were prepared by film-dispersing and high-pressure homegenization technique using soybean phospholipid and soybean oil as matrix. The entrapment efficiency and drug loading capacity were determined by HPLC. The morphology was examined by transmission electron microscope and the mean particle size was measured by laser light scattering technique.
RESULTS: The products were spherical and well distributed. The mean diameter was (161+/-17.4) nm with (85.1+/-0.83)% of entrapment efficiency and (5.3+/-0.2)% of drug loading. The in vitro release test showed that the Art-IS-NLC had good sustained release characteristics.
CONCLUSION: The preparation method of Art-IS-NLC is simple and feasible. The products are well distributed with a high entrapment efficiency. | | Language | chi | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19764583 |
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